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Neurotoxicity in Clinical Practice

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Session #2 of 8 
Annual Updates in Environmental Medicine Conference
"Environmental Causes of Common Chronic Neurological Problems
Headaches to Parkinsonism" 

Neurotoxicity in Clinical Practice 

Presented by Bill Rea, MD

One hundred non-smoking, non-diabetic, non-alcoholic patients were studied (61 females, 39 males, ages 12-75 years old, average of 45 years), who had chronic ambient doses (which were not considered as high levels) of chemical exposure (solvents and chlorinated pesticides) in the ambient air for at least one year at their work place. The patients used no protective gear. The main complaints were central neurological symptoms in 100% (headaches, migraines, short-term memory loss, inability to concentrate, vertigo, lightheadedness). In addition, fibromyalgia, fatigue, arthritis, arthralgia, and musculoskeletal pains were also observed in 51% of the patients. All patients had common observable physical findings such as not being able to stand on their toes or walk a straight line with their eyes closed (stressed and tandem Romberg). Toxicity and sensitivity were confirmed by triple headed brain SPECT scan (81/81), computerized posturography (79%), pupillography (86%), heart rate variability (9/9), and serum levels of the toxics (3.98 per patient). Total lymphocytes, T11, T4, and T8 lymphocytes were abnormal in 100% of the 91 patients measured. Cell mediated immunity was abnormal in 46% of the 78 patients measured. Intradermal skin testing for chemicals in 76 patients resulted in positive reactions. 280 double blind inhaled challenges (15 minutes of exposure at the ambient doses), after 4 days of deadaptation in a less polluted environment, were performed on 30 patients. Positive reactions occurred to the ambient doses of chlorine, organophosphate pesticides, formaldehyde, ethanol, xylene and toluene. 10% of patients reacted to the 60 saline placebos challenged. 


At the conclusion of this educational activity, participants will be able to:

  1. Understand the symptoms and signs of chemical exposure and neurotoxicity. 

  2. Understand the immune aspects of both. 

  3. Understand the different triggering agents of chemical sensitivity and neurotoxicity. 

Bill Rea, MD 

William J. Rea, M.D., is a thoracic and cardiovascular surgeon with a strong passion for the environmental aspects of health and disease. Founder of the Environmental Health Center (EHC-D), Dr. Rea is currently director of this highly specialized Dallas based medical facility.In 1988, Dr. Rea was named to the world’s first professorial chair of environmental medicine at the Robens Institute of Toxicology at the University of Surrey in Guildford, England. He was also awarded the Jonathan Forman Gold Medal Award in 1987 and the Herbert J. Rinkel Award in 1993, both by the American Academy of Environmental Medicine, as well as named Outstanding Alumnus by Otterbein College in 1991.

He was also named to the Mountain Valley Water Hall of Fame for work in the field of study of clean water and, in 1995, he received the F.A.M.E. Award for pioneering work in environmental and preventive medicine. In 1997 he was named International Man of the Year and in 2002 Dr. Rea received the O. Spurgeon English Humanitarian Award from Temple University.


Purchase Includes:

  • 30-day access to recording
  • Lecture slides and handouts (if applicable) are yours to keep
  • CE Certificate - 1.50 General Credit Hours by the Oregon Board of Naturopathic Medicine (OBNM)